To start the piece, we'll be using alternate picking to play a riff spanning over strings 3 through 6. We'll be playing sixteenth notes exclusively.
Also, when you look at the tablature, be sure to observe the palm mutes throughout. You'll be palm muting all the notes on the Low E and A strings.
Keep your alternate picking steady as you go from string to string. Pretty much every note you play will be followed by a note on a different string, so it's imperative that you keep your picking smooth and consistent.